Unemployment Rate in St. Louis City, MO was 4.80% in March of 2026, according to the United States Federal Reserve. Historically, Unemployment Rate in St. Louis City, MO reached a record high of 12.90 in May of 2020 and a record low of 2.30 in September of 2022. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in St. Louis City, MO - last updated from the United States Federal Reserve on May of 2026.